Archive

In vivo Corneal confocal microscopy: Basic principles and applications Journal > /en/journal/2017/4/5
Corneal confocal microscopy is a new, non-invasive imaging method. It provides serial images of a face optical sections through the full-thickness of the living cornea, avoiding artefacts associated with ex vivo study. It provides qualitative as well as quantitative analysis of the corneal layers, nerves, and cells. It also allows longitudinal examination of the corneal structure changes over time...
Possibilities od in vivo corneal confocal microscopy of corneal nerves in diabetes Journal > /en/journal/2017/4/6
In vivo corneal confocal microscopy (CCM) represents a new, non-invasive, rapidly developing corneal examination technique that enables individual layers of the cornea to be displayed at the cellular level. The cornea is the translucent and at the same time the most innervated tissue of the human body. Diabetic neuropathy (DN) is a serious complication of diabetes mellitus (DM). A close correlatio...
The Effect of Therapy on the Ocular Surface in Patients with Unilateral Paediatric Glaucoma Journal > /en/journal/2021/1/4
Purpose: The aim of the study was to evaluate ocular surface and tear film in patients with pediatric (primary or secondary) unilateral glaucoma and compare results obtained from the treated eye and untreated healthy eye. Methods: Patients with unilateral pediatric glaucoma, followed in the outpatient department of the Department of Ophthalmology, Motol University Hospital, were included in this s...
Modern Biomarkers for Early Diagnosis of Ocular Surface Disease in Type 1 Diabetes. A Pilot Study Journal > /en/journal/2025/3/2
Patients with dry eye syndrome form a significant proportion of those treated in everyday ophthalmology practice. Diabetes mellitus is a major risk factor for the development of dry eye syndrome. Changes in tear film homeostasis, chronic inflammation and subsequent corneal nerve fiber pathology play a key role in its progression.The aim of this study was to describe the status of modern biomarkers...
Tear Osmolarity in Patients with Lagophthalmos Journal > /en/journal/2016/5/2
Introduction: Lagophthalmos can be characterized as the dysfunction of the eye aperture and in some cases even by the disruption of tear production. Dry eye syndrome can consequently develop. Instability of the tear film, hyperosmolarity and inflammatory reaction are considered as the key mechanisms of dry eye syndrome. In our report we monitored the tear osmolarity of patients with postsurgical u...
Tear Osmolarity in Patients with Severe Dry Eye Syndrome Before and After Autologous Serum Treatment: a Comparison with Tear Osmolarity in Healthy Volunteers Journal > /en/journal/2015/4/1
Introduction: Dry eye syndrome (DES) is a multifactorial disease of the tears and ocular surface. Recently, treatment with autologous serum eye drops (AS-ed) has been frequently used in these patients. Significant improvement correlates well with clinical, laboratory and subjective findings. It is assumed that one of the key factors in the development of the disease is increased tear osmolarity. T...